Gurpal Virdi, MD

AI Research

AI in ophthalmology, and the evaluation of frontier AI.

I am an ophthalmologist who builds machine-learning systems for eye surgery, and who works with frontier AI labs and AI startups on reinforcement learning and the evaluation of large language models. The two halves inform each other more than they look like they should.

AI & technology in ophthalmology

Most of my applied work does one thing: it uses machine learning to make a prediction a surgeon currently has to make from a proxy measurement. Four projects, all doing that.

ProjectWhat it isWhat it does
ICL FitDeployed AI sizing agent, previously published as VAULT-OCT. Co-founded, and I lead the engineeringIdentifies the best-fitting EVO ICL size for an individual eye from its own anterior-segment imaging, trained on real surgical outcomes, used before a case rather than sitting in a paper
VAULT & VAULT-OCTThe peer-reviewed models behind it, Journal of Cataract & Refractive SurgeryPredict what each lens size does in a specific eye from anterior-segment imaging, instead of inferring the sulcus from white-to-white corneal diameter
IOL ReferenceIntraocular lens technology platform. Built and maintained by meLets cataract surgeons compare lens designs, optical principles, materials, power and toricity ranges, constants and specifications side by side
EyeLabs AIThe company behind the workBuilds AI tools for modern ophthalmology

IOL Reference is structured data rather than a model, and that is deliberate. Choosing an implant is the least instrumented step in modern cataract surgery, and before you can reason about lens selection computationally you need the lens data in a form a machine can read.

What connects all of it: the parts of eye surgery machine learning has actually improved are the ones where an outcome depends on anatomy nobody can measure directly. ICL vault is one. Intraocular lens power is another, which is why several of the best modern IOL formulas are machine-learning models trained on tens of thousands of real outcomes. The parts it has not improved are the counselling decisions, which depend on what a person does for a living and what they want from their vision. Where that line sits today.

Frontier AI: reinforcement learning and evaluation

I build reinforcement-learning environments and evaluation harnesses that train and measure frontier models, spanning agentic coding agents, tool use, and reasoning. The environments pose real, verifiable tasks in sandboxed execution with automated reward and verification (RLHF and reinforcement learning from verifiable rewards), so models can be trained and benchmarked at scale against ground truth.

The tasks run deep into ML systems and GPU work: CUDA, Triton and Pallas kernels, distributed training (FSDP, ZeRO, NCCL), optimizer internals, and high-throughput inference (vLLM), alongside full-stack software engineering and infrastructure.

Medical-AI evaluation

As a physician, I focus on the part where my two fields meet: evaluating medical AI. I build rubric-based health benchmarks in which frontier models are graded against physician-written criteria for accuracy, completeness, safety, and communication, with model-based graders validated against physician judgment. It is the same problem as the clinic: measuring performance honestly against the standard of an expert.

Focus areas

Reinforcement learning RL environments RLHF & verifiable rewards LLM evaluation Reward modeling Agentic coding agents Frontier & foundation models GPU kernels (CUDA · Triton · Pallas) Distributed training (FSDP · ZeRO · NCCL) Computer vision AI in ophthalmology ICL sizing & vault prediction (VAULT · VAULT-OCT) Anterior-segment OCT Intraocular lens technology (IOL Reference) Surgical decision support (ICL Fit) Medical-AI evaluation

Related: ICL sizing & vault research · cataract surgery & IOL selection · blog · CV

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